鲍姆桑黄孔菌化合物对HepG2细胞葡萄糖消耗的影响及其作用机制的研究Compounds of Sanghuangporus baumii and their affecting mechanism of glucose consumption in insulin-resistant HepG2 cells
张超;汪雯翰;杨焱;颜梦秋;冯娜;张劲松;
摘要(Abstract)：
利用胰岛素抵抗HepG2细胞模型筛选具有降血糖活性的鲍姆桑黄孔菌菌丝体化合物,并对其作用机理进行了初步探讨。研究结果表明从鲍姆桑黄孔菌大米发酵菌丝体中分离出的原儿茶醛、柚皮素和黄芩素3种化合物对HepG2细胞葡萄糖消耗量具有明显的促进作用;实时定量PCR分析表明,原儿茶醛对SOCS-3因子mRNA表达抑制效果最好,而黄苓素对TNF-α因子mRNA表达抑制效果最佳。原儿茶醛和黄芩素为鲍姆桑黄孔菌中有降血糖活性的化合物。
关键词(KeyWords)： 鲍姆桑黄孔菌;HepG2细胞;胰岛素抵抗;细胞因子信号抑制因子-3;肿瘤坏死因子-α
基金项目(Foundation): 国家十二五科技支撑课题(2012BAD36B05)~~
作者(Authors): 张超;汪雯翰;杨焱;颜梦秋;冯娜;张劲松;
DOI: 10.13346/j.mycosystema.150104
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