朱伟明;王俊锋;

• 1:海洋药物教育部重点实验室中国海洋大学医药学院

摘要(Abstract)：

海洋真菌是活性海洋天然产物的重要来源,到目前为止,已从海洋真菌的发酵产物中分离鉴定了1,117个新化合物。介绍了海洋真菌次生代谢产物的研究历史、现状、特点、研究方法、存在问题及其在新药研究中的应用前景。

关键词(KeyWords)： 海洋真菌;次生代谢;活性产物;含氮化合物;卤代物

Abstract:

Keywords:

基金项目(Foundation): 国家“973”项目“海洋微生物次生代谢的生理生态效应及其生物合成机制”(No.2010CB83380);; 国家自然科学基金项目“嗜盐微生物抗肿瘤活性成分的研究”(No.30670219)

作者(Authors): 朱伟明;王俊锋;

DOI: 10.13346/j.mycosystema.2011.02.024

参考文献(References)：

• Abraham EP,Newton GGF,Crawford K,Burton HS,Hale CW,1953.Cephalosporin N:a new type of penicillin.Nature,171:343
• Biabani MAF,Hartmut L,1998.Advances in chemical studies on low-molecular weight metabolites of marine fungi.Journal Fur Praktische Chemie,340(7):589-607
• Blunt JW,Copp BR,Hu WP,Murray HGM,Northcote PT,Prinsep MR,2009.Marine natural products.Natural Product Reports,26(2):170-244
• Bode HB,Bethe B,Hfs R,Zeeck,A.2002.Big effects from small changes:possible ways to explore nature’s chemical diversity.ChemBioChem,3(7):619-627
• Bugni TS,Ireland CM,2004.Marine-derived fungi:a chemically and biologically diverse group of microorganisms.Natural Product Reports,21(1):143-163
• Chen L,Fang YC,Zhu TJ,Gu QQ,Zhu WM,2008.Nine new gentisyl alcohol derivatives from marine-derived fungus Penicillium terrestre.Journal of Natural Products,71(1):66-70
• Costantino V,Fattorusso E,Menna M,Taglialatela-Scafati O,2004.Chemical diversity of bioactive marine natural products:an illustrative case study.Current Medicinal Chemistry,11(13):1671-1692
• Frenz JL,Kohl AC,Kerr RG,2004.Marine natural products as therapeutic agents:Part2.Expert Opinion Therapeutic Patents,14(1):17-33
• Grabley S,Thiericke R,Zeeck A,2000.The chemical screening approach.In:Grabley S,Thiericke R(eds.)Drug discovery from nature.Springer,Verlag Berlin Heidelberg.124-148
• Hill RA,Sutherland A,2005.Hot off the press.Natural Product Reports,22(5):559-562
• Hill RA,Sutherland A,2008.Hot off the press.Natural Product Reports,25(1):11-14
• Hyde KD,Jones EBG,Leao E,Pointing SB,Poonyth AD,Vrijmoed LLP,1998.Role of fungi in marine ecosystems.Biodiversity and Conservation,7(9):1147-1161
• Hyde KD,Sarma VV,Jones EBG,2000.Morphology and taxonomy of higher marine fungi.In:Hyde KD,Pointing SB(eds.)Marine mycology-a practical approach.Fungal Diversity Press,Hong Kong.172-204
• Kohlmeyer J,Kohlmeyer E,1979.Marine mycology:the higher fungi.Academic Press,New York,San Francisco&London.35-45
• Lin ZJ,Lu ZY,Zhu TJ,Fang YC,Gu QQ,Zhu WM,2008.Penicillenols from Penicillium sp.GQ-7,an endophytic fungus associated with Aegiceras corniculatum.Chemical and Pharmaceutical Bulletin,56(2):217-221
• Liu R,Gu QQ,Zhu WM,Cui CB,Fan GT,Fang YC,Zhu TJ,Liu HB,2006.10-Phenyl-[12]-cytochalasins Z7,Z8,and Z9from the marine-derived fungus Spicaria elegans.Journal of Natural Products,69(6):871-875
• Liu R,Lin ZJ,Zhu TJ,Fang YC,Gu QQ,Zhu WM,2008.Novel open-chain cytochalsins from the marine-derived fungus Spicaria elegans.Journal of Natural Products,71(7):1127-1132
• Liu WZ,Gu QQ,Zhu WM,Cui CB,Fan GT,2005a.Dihydrotrichodimerol and tetratrichodimerol,two new bisorbicillinoids,from a marine-derived Penicillium terrestre.Journal of Antibiotics,58(10):621-624
• Liu WZ,Gu QQ,Zhu WM,Cui CB,Fan GT,2005b.Two new benzoquinone derivatives and two new bisorbicillinoids were isolated from a marine-derived fungus Penicillium terrestre.Journal of Antibiotics,58(7):441-446
• Liu WZ,Gu QQ,Zhu WM,Cui CB,Fan GT,Zhu TJ,Liu HB,Fang YC,2005c.Penicillones A and B,two novel polyketides with tricyclo[5.3.1.03,8]undecane skeleton,from a marine-derived fungus Penicillium terrestre.Tetrahedron Letters,46(30):4993-4996
• Lu ZY,Wang Y,Miao CD,Liu PP,Hong K,Zhu WM,2009.Sesquiterpenoids and benzofuranoids from the marine-derived fungus Aspergillus ustus094102.Journal of Natural Products,72(10):1761-1767
• Lu ZY,Zhu HJ,Fu P,Wang Y,Zhang ZH,Lin HP,Liu PP,Zhuang YB,Hong K,Zhu WM,2010.Cytotoxic polyphenols from the marine-derived fungus Penicillium expansum.Journal of Natural Products,73(5):911-914
• Mayer AM,Glaser KB,Cuevas C,Jacobs RS,Kem W,Little RD,McIntosh JM,Newman DJ,Potts BC,Shuster DE,2010.The odyssey of marine pharmaceuticals:a current pipeline perspective. Trends in Pharmacological Sciences,31(6):255-265
• Méjanellel L,Lòpez JF,Gunde-Cimerman N,Grimalt JO,2001.Ergosterol biosynthesis in novel melanized fungi from hypersaline environments.Journal of Lipid Research,42(3):352-358
• Monaghan RL,Polishook JD,Pecore VJ,Bills GF,Nallin-Omstead M,Streicher SL,1995.Discovery of novel secondary metabolites from fungi-is it really a random walk through a random forest?Canadian Journal of Botany,73(Suppl.):S925-S931
• Moore BS,2005.Biosynthesis of marine natural products:microorganism.Natural Product Reports,22(5):580-593
• Newton GGF,Abraham EP,1955.Cephalosporin C,a new antibiotic containing sulphur and D--aminoadipic acid.Nature,175:548
• Park JM,Park CJ,Lee SB,Ham BK,Shin R,Paek KH,2010.Overexpression of the tobacco tsi1gene encoding an EREBP/AP2-type transcription factor enhances resistance against pathogen attack and osmotic stress in tobacco.Plant Cell,13(5):1035-1046
• Pelzer S,Vente A,Bechthold A,2005.Novel Natural compounds obtained by genome-based screening and genetic engineering.Current Opinion in Drug Discovery and Development,8(2):228-238
• Rateb ME,Ebel R,2011.Secondary metabolites of fungi from marine habitat.Natural Product Reports,28(2):290-344
• Saleem M,Ali MS,Hussain S,Jabbar A,Ashraf M,Lee YS,2007.Marine natural products of fungal origin.Natural Product Reports,24(5):1142-1152
• Sashidhara KV,White KN,Crews P,2009.A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products.Journal of Natural Products,72(3):588-603
• Tang RH,1996.Introduction.In:Wang K(ed.)Trace elements in the life sciences(second edition).China Metrology Publishing House,Beijing.1-62(in Chinese)
• Wang FZ,Fang YC,Zhu TJ,Zhang M,Lin AQ,Gu QQ,Zhu WM,2008.Seven new prenylated indole diketopiperazine alkaloids from holothurian-derived fungus Aspergillus fumigatus.Tetrahedron,64(34):7986-7991
• Wang WL,Liu PP,Zhang YP,Li J,Tao HW,Gu QQ,Zhu WM,2009a.2-Hydroxydiplopterol,a new cytotoxic pentacyclic triterpenoid from the halotolerant fungus Aspergillus variecolor B-17.Archives of Pharmacal Research,32(9):1211-1214
• Wang WL,Lu ZY,Tao HW,Zhu TJ,Fang YC,Gu QQ,Zhu WM,2007a.Isoechinulin-type alkaloids,variecolorin A-L,from halotolerant Aspergillus variecolor.Journal of Natural Products,70(10):1558-1564
• Wang WL,Wang Y,Tao HW,Peng XP,Liu P,Zhu WM,2009b.Cerebrosides of the halotolerant fungus Alternaria raphani isolated from a sea salt field.Journal of Natural Products,72(9):1695-1698
• Wang WL,Zhu TJ,Tao HW,Lu ZY,Fang YC,Gu QQ,Zhu WM,2007b.Two new cytotoxic quinone type compounds from the halotolerant fungus Aspergillus variecolor.Journal of Antibiotics,60(10):603-607
• Wang WL,Zhu TJ,Tao HW,Lu ZY,Fang YC,GU QQ,Zhu WM,2007c.Three novel,structurally unique spirocyclic alkaloids from the halotolerant b-17fungus strain of Aspergillus variecolor.Chemistry&Biodiversity,4(12):2913-2919
• Xin ZH,Fang YC,Du L,Zhu TJ,Duan L,Chen J,Gu QQ,Zhu WM,2007.Aurantiomides A-C,quinazoline alkaloids from the sponge-derived fungus Penicillium aurantiogriseum SP0-19.Journal of Natural Products,70(5):853-855
• Xin ZH,Gu QQ,Zhu WM,Fang YC,Duan L,Cui CB,2005.A new cytotoxic compound from Penicillium auratiogriseum,symbiotic or epiphytic fungus of sponge Mycale plumose.Chinese Chemical Letters,16(9):1227-1229
• Zhang M,Wang WL,Fang YC,Zhu TJ,Gu QQ,Zhu WM,2008a.Cytotoxic alkaloids and antibiotic nor-dammarane triterpenoids from marine-derived fungus Aspergillus sydowi.Journal of Natural Products,71(6):985-989
• Zhang YP,Ling S,Fang YC,Zhu TJ,Gu QQ,Zhu WM,2008b.Two New naphtho-γ-pyrones dimers and their antimycobacterial activity from marine-derived fungus Aspergillus carbonarius.Chemistry and Biodiversity,5(1):93-100
• Zhang YP,Zhu TJ,Fang YC,Liu HB,Gu QQ,Zhu WM,2007.Carbonarones A and B,new bioactiveγ-pyrone andα-pyridone derivatives from the marine-derived fungus Aspergillus carbonarius.Journal of Antibiotics,60(2):153-157
• Zhang YP,Zhu WM,Gu QQ,Zhu TJ,2006.New advances in studies of antitumor compounds from marine fungi.Chinese Journal of Marine Drugs,25(1):54-58(in Chinese)
• Zheng JK,Xu ZH,Wang Y,Hong K,Liu PP,Zhu WM,2010.Cyclic tripeptides from the halotolerant fungus Aspergillus sclerotiorum PT06-1.Journal of Natural Products,73(6):1133-1137
• Zheng JK,Zhu HJ,Hong K,Wang Y,Liu PP,Wang X,Peng XP,Zhu WM,2009.Novel cyclic hexapeptides from marine-derived fungus,Aspergillus sclerotiorum PT06-1.Organic Letters,11(22):5262-5265
• Zhou YL,Wang Y,Liu PP,Wang ZY,Zhu WM,2010.Effects of environmental stress on secondary metabolites of Aspergillus ochraceus LCJ11-102associated with the coral Dichotella gemmacea.Acta Microbiologica Sinica,50(8):1023-1029(in Chinese)
• 唐任寰,1996.生命科学中的微量元素(第二版,主编:王夔).第一章导言.北京:中国计量出版社.1-62
• 张亚鹏,朱伟明,顾谦群,朱天娇,2006.源于海洋真菌抗肿瘤活性物质的研究进展.中国海洋药物杂志,25(1):54-58
• 周雅琳,王乂,刘培培,王智颖,朱伟明,2010.环境胁迫对珊瑚共附生真菌Aspergillus ochraceus LCJ11-102次生代谢产物的影响.微生物学报,50(8):1023-1029