李春怡;王晓岩;

• 1:长春科技学院医药学院
• 2:吉林农业科技学院中药学院

摘要(Abstract)：

多脂鳞伞Pholiota adiposa是一种珍贵的食药用真菌。本文研究了多脂鳞伞子实体中提取的真菌多糖(PAP)对高脂饮食联合链脲佐菌素诱导的2型糖尿病小鼠的抗糖尿病作用。研究表明，PAP治疗组的空腹血糖水平显著降低，体重增加，并且三酰甘油(TG)、总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)的水平降低，而超氧化物歧化酶(SOD)、高密度脂蛋白胆固醇(HDL-C)的水平、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-Px)在PAP治疗组中显著增加。模型组的胰腺和肝脏组织表现出显著的病理学变化，PAP治疗组具有改善作用，PAP治疗组胰岛形态和功能显著恢复，此外，蛋白质印迹分析表明，PAP处理后PI3K、AKT、p-AKT、p-IRS1、IRS1、GSK3β和p-GSK3β等蛋白的表达增加，PI3K、p-AKT等信号通路与胰岛素抵抗的减轻相关。综上所述，PAP能降低小鼠空腹血糖水平、调节机体氧化应激性、保护肝脏及胰腺等器官并且能够介导PI3K、p-AKT等信号通路起到预防和治疗糖尿病的作用。

关键词(KeyWords)： 多脂鳞伞;Ⅱ型糖尿病;生理生化指标;免疫组化;蛋白质印迹

Abstract:

Keywords:

基金项目(Foundation): 吉林省教育厅科学技术研究项目(JJKH20220397KJ)~~

作者(Authors): 李春怡;王晓岩;

DOI: 10.13346/j.mycosystema.210430

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