陈丽庄;钱一鑫;康冀川;王鲁;卢永仲;范翠;何张江;

• 1:贵州大学西南特色药用生物资源开发利用教育部工程研究中心
• 2:贵州大学酿酒与食品工程学院
• 3:贵州理工学院

摘要(Abstract)：

高水平的多药耐药性(multidrug resistance,MDR)基因在肿瘤细胞中过量表达是肿瘤细胞耐药的内在原因,是导致肿瘤化疗失败的主要原素。寻求一种抑制MDR活性的抑制剂是提升抗肿瘤药物药效的重要途径。本研究采用低浓度持续诱导方法建立人乳腺癌细胞(MCF-7)耐药细胞系,结果显示,阿霉素(ADM)、紫杉醇和顺铂对MCF-7耐药细胞系有交叉耐药性,耐药指数(resistance index,RI)分别为5.11、3.55和1.79。菌株对肿瘤细胞的逆转活性筛选表明,红棕毛筒腔菌TubeufiarubraPF02-2和河池毛筒腔菌T. hechiensis XSL05具有逆转肿瘤细胞多药耐药性为敏感性的活性,逆转倍数(reversion fold,RF)分别为3.79和1.07。结果表明,T. rubra和T. hechiensis具有开发为MDR逆转剂的潜能。

关键词(KeyWords)： 多药耐药性;人乳腺癌阿霉素耐药细胞株;毛筒腔菌属真菌;次级代谢产物

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(31670027);; 贵州大学培育项目(黔科合平台人才[2017]5788)~~

作者(Authors): 陈丽庄;钱一鑫;康冀川;王鲁;卢永仲;范翠;何张江;

DOI: 10.13346/j.mycosystema.190451

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