张耀;刘如明;肖建辉;

• 1:遵义医学院附属医院贵州省转化医学工程研究中心微生物资源及药物研究室

摘要(Abstract)：

真菌栖息生境及物种的多样性使其次级代谢产物化学结构和生物活性呈多样性特点,结构与功能多样的真菌次级代谢产物已成为新药先导化合物发现的重要资源。低温型真菌因其独特而恶劣的生存环境进化出特有的适冷特性及代谢途径,使其产生结构新颖、活性显著的次级代谢产物的几率大大提升,已成为药物研发的热点领域。近年来,研究者陆续从高海拔地区、南北极地和深海地带等低温生境分离鉴定出上百种结构新颖的次级代谢产物,并显示出抗肿瘤、抗菌、抗病毒和免疫调节等多种活性。本文对近10年来源于上述生境的低温型真菌抗肿瘤活性次级代谢产物的研究进展进行综述,为其用于创制抗肿瘤新药提供新思路。

关键词(KeyWords)： 低温型真菌;次级代谢产物;抗肿瘤活性

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81060260);; 贵州省科技创新人才团队建设专项资金[黔科合人才团队(2013)4035];; 贵州省中医药管理局科学技术研究专项(QZyy-2014-073)~~

作者(Authors): 张耀;刘如明;肖建辉;

DOI: 10.13346/j.mycosystema.150001

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